解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Kisspeptins are hypothalamic neuropeptides encoded by KISS1 and recently described as major regulators of GnRH release from hypothalamic neurons. Although 17beta-estradiol (E2)-induced up-regulation of KISS1 expression has been documented in anteroventral periventricular nucleus neurons, E2 down-regulates KISS1 expres...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2010-0260
更新日期:2010-08-01 00:00:00
abstract::We have examined the effects of acute administration of the cannabinoid receptor type 1 (CB(1)) antagonist AM251 on the rat hypothalamic-pituitary-adrenal (HPA) axis with respect to both gender and time of day. Blood samples were collected from conscious male and female rats every 5 min using an automated blood sampli...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2010-0101
更新日期:2010-08-01 00:00:00
abstract::Oscillations in intracellular calcium levels have been described in GnRH-1 neurons in both prenatal and adult cells. However, differences have been reported in the mechanisms underlying these [Ca(2+)](i) oscillations, dependent on the model used. The goal of this study was to address whether these changes depend on th...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2010-0118
更新日期:2010-08-01 00:00:00
abstract::Covalent adduction of a nitrosyl group to cysteines [S-nitrosylation (S-NO)] is emerging as a key route for nitric oxide (NO) to directly modulate protein functions. Here, we studied the effects of estrogens on endothelial protein S-NO and analyzed the nitrosyl-proteomes by biotin/CyDye switch technique combined with ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-1356
更新日期:2010-08-01 00:00:00
abstract::Recently, a subset of neurons was identified in the arcuate nucleus of the hypothalamus that colocalize three neuropeptides, kisspeptin, neurokinin B, and dynorphin, each of which has been shown to play a critical role in the central control of reproduction. Growing evidence suggests that these neurons, abbreviated as...
journal_title:Endocrinology
pub_type: 杂志文章,评审
doi:10.1210/en.2010-0022
更新日期:2010-08-01 00:00:00
abstract::IL-6 abundance in amniotic fluid and uterine tissues increases in late gestation or with infection-associated preterm labor. A role in regulation of labor onset is suggested by observations that IL-6 increases expression of genes controlling prostaglandin synthesis and signaling in isolated uterine cells, but whether ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2010-0063
更新日期:2010-08-01 00:00:00
abstract::A member of the interferon-inducible p200 family of proteins, p204, has recently been reported to function in the development of many mesoderm-derived tissues, such as bone, muscle, and cartilage. However, no published study has yet investigated the role of p204 in adipogenesis. Our preliminary experiments showed that...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-1381
更新日期:2010-07-01 00:00:00
abstract::Prolactin (PRL) is tonically inhibited by dopamine (DA) released from neurons in the arcuate and periventricular nuclei. Kisspeptin plays a pivotal role in LH regulation. In rodents, kisspeptin neurons are found mostly in the anteroventral periventricular and arcuate nuclei, but the physiology of arcuate kisspeptin ne...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-1414
更新日期:2010-07-01 00:00:00
abstract::We recently reported that bone morphogenetic proteins (BMPs) 2 and 4 can stimulate FSHbeta-subunit (Fshb) transcription alone and in synergy with activins. We further showed that BMP2 signals via the BMP type IA receptor (or activin receptor-like kinase 3) to mediate its effects. However, the intracellular mechanisms ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2010-0071
更新日期:2010-07-01 00:00:00
abstract::Chemerin is an adipokine with important regulatory roles in adipogenesis. In humans, serum total chemerin (i.e. prochemerin plus chemerin) levels are positively associated with body mass index and metabolic syndrome. However, the mechanisms that increase serum chemerin concentration are unknown. We hypothesized that c...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-0794
更新日期:2010-06-01 00:00:00
abstract::Within the preoptic region, nitric oxide (NO) production varies during the ovarian cycle and has the ability to impact hypothalamic reproductive function. One mechanism for the regulation of NO release mediated by estrogens during the estrous cycle includes physical association of the calcium-activated neuronal NO syn...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2010-0007
更新日期:2010-06-01 00:00:00
abstract::We recently described a novel GnRH receptor signaling pathway mediated by the prostaglandins (PGs) F(2alpha) and PGI(2), which acts through an autocrine/paracrine modality to limit autoregulation of the GnRH receptor and inhibit LH but not FSH release. Here we further explore the cross talk between GnRH and the PG rec...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-1335
更新日期:2010-06-01 00:00:00
abstract::Sex chromosome imbalance in males is linked to a supernumerary X chromosome, a condition resulting in Klinefelter syndrome (KS; 47, XXY). KS patients suffer from infertility, hypergonadotropic hypogonadism, and cognitive impairments. Mechanisms of KS pathophysiology are poorly understood and require further exploratio...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-1396
更新日期:2010-06-01 00:00:00
abstract::Androgens act to stimulate spermatogenesis through androgen receptors (ARs) on the Sertoli cells and peritubular myoid cells. Specific ablation of the AR in either cell type will cause a severe disruption of spermatogenesis. To determine whether androgens can stimulate spermatogenesis through direct action on the peri...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-1333
更新日期:2010-05-01 00:00:00
abstract::Neurons in the rodent anteroventral periventricular nucleus (AVPV) play a key role in integrating circadian and gonadal steroid hormone information in the control of fertility. In particular, estradiol-sensitive kisspeptin neurons located in the AVPV, and adjacent structures [together termed the rostral periventricula...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-1480
更新日期:2010-05-01 00:00:00
abstract::Several neuropeptides with the C-terminal RFamide sequence have been identified in the hypothalamus of a variety of vertebrates. Among the RFamide peptide groups, however, only LPXRFamide peptides, including gonadotropin-inhibitory hormone, have been characterized in the avian brain. In the present study, we sought fo...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-1478
更新日期:2010-05-01 00:00:00
abstract::We recently found that the Japanese red-bellied newt, Cynops pyrrhogaster, actively produces 7alpha-hydroxypregnenolone, a previously undescribed amphibian neurosteroid. 7alpha-Hydroxypregnenolone stimulates locomotor activity of male newts. Locomotor activity of male newts increases during the breeding period as in o...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-1229
更新日期:2010-05-01 00:00:00
abstract::Recent studies suggest that hyperinsulinemia and insulin resistance are linked to Alzheimer's disease (AD). In this study, we used Tg2576 transgenic (Tg) mice, a widely used transgenic mouse model for AD, to explore the relationship between increased amyloid beta-peptide (Abeta) and insulin resistance. When fed a high...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-1196
更新日期:2010-04-01 00:00:00
abstract::Childhood obesity increases the risk of adult obesity and diabetes, suggesting that early overnutrition permanently programs altered energy and glucose homeostasis. In the present studies, we used a mouse model to investigate whether early overnutrition increases susceptibility to obesity and insulin resistance in res...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-1295
更新日期:2010-04-01 00:00:00
abstract::Local release of TGF-beta during times of high bone turnover leads to elevated levels within the bone microenvironment, and we have shown that TGF-beta suppresses osteoclast apoptosis. Therefore, understanding the influences of TGF-beta on bone resorbing osteoclasts is critical to the design of therapies to reduce exc...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-0813
更新日期:2010-04-01 00:00:00
abstract::Identification of RF-amide-related peptides (RFRP), as putative mammalian orthologs of the avian gonadotropin-inhibitory hormone, has drawn considerable interest on its potential effects and mechanisms of action in the control of gonadotropin secretion in higher vertebrates. Yet, these analyses have so far relied most...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-1259
更新日期:2010-04-01 00:00:00
abstract::The pregnane X receptors (PXRs) and the constitutive androstane receptor (CAR) were initially isolated as nuclear receptors regulating xenobiotic metabolism and elimination, alleviating chemical insults. However, recent works suggest that these xenoreceptors play an endobiotic role in modulating hepatic lipid metaboli...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-1435
更新日期:2010-04-01 00:00:00
abstract::Chronically elevated circulating glucocorticoid levels are although to enhance vulnerability to psychopathology. Here we hypothesized that such sustained glucocorticoid levels, disturbing corticosterone pulsatility, attenuate glucocorticoid receptor signaling and target gene responsiveness to an acute challenge in the...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-1119
更新日期:2010-03-01 00:00:00
abstract::In this study we tested the hypothesis that receptor-mediated transport of urocortin across the blood-brain barrier (BBB) undergoes developmental changes. Urocortin is a peptide produced by both selective brain regions and peripheral organs, and it is involved in feeding, memory, mood, cardiovascular functions, and im...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-1039
更新日期:2010-03-01 00:00:00
abstract::Mutations in the GnRH receptor gene (GNRHR) can result in hypogonadotropic hypogonadism in humans. Unlike most mammals, mice lack a second form of GnRH (GnRH2) and a type 2 GnRH receptor. To determine whether the GnRH receptor is critical at all stages of reproduction and whether this receptor has additional physiolog...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-0598
更新日期:2010-03-01 00:00:00
abstract::Nuclear receptor function on DNA is regulated by the balanced recruitment of coregulatory complexes. Recruited proteins that increase gene expression are called coactivators, and those that decrease gene expression are called corepressors. Little is known about the role of corepressors, such as nuclear receptor corepr...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-0594
更新日期:2010-03-01 00:00:00
abstract::Acute leptin increase as well as endogenous hyperleptinemia evoked by high-fat diets (HF) activate fatty acid metabolism in nonadipose tissues. This supports the notion that hyperleptinemia is pivotal to prevent/delay steatosis during periods of positive energy balance. We have previously shown that long-term HF spare...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-1170
更新日期:2010-03-01 00:00:00
abstract::Hypothalamic proopiomelanocortin (POMC)-derived MSH peptides and the melanocortin receptor antagonist, agouti-related protein (AgRP), interact to regulate energy balance. Both POMC and AgRP neurons express estrogen receptors, but little is known about estrogen regulation of the melanocortin system in the primate. We h...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-0853
更新日期:2010-03-01 00:00:00
abstract::Hypothalamic insulin signaling is essential to the maintenance of glucose and energy homeostasis. During pathological states, such as obesity and type 2 diabetes mellitus, insulin signaling is impaired. One key mechanism involved in the development of insulin resistance is lipotoxicity, through increased circulating s...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-1122
更新日期:2010-02-01 00:00:00
abstract::Nucleic acid-based therapies offer great potential for treatment of a variety of diseases including cancer by modulating protein expression with DNA or small interfering RNA. However, realization of their full therapeutic potential is currently limited due to an inability to reach the target site in an active form. Id...
journal_title:Endocrinology
pub_type: 杂志文章,评审
doi:10.1210/en.2009-1045
更新日期:2010-02-01 00:00:00
abstract::Nutritional programming, taking place in utero or early after birth, is closely linked with metabolic and appetite disorders in adulthood. Following the hypothesis that nutritional programming impacts hypothalamic neuronal organization, we report on discrepancies of multiple molecular and cellular early events that ta...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-0893
更新日期:2010-02-01 00:00:00
abstract::T(4) must be activated by its monodeiodination to T(3) by type 1 or 2 iodothyronine deiodinase (D1 and D2). Recent studies show that despite an approximately 2000-fold higher Michaelis constant (K(m); T(4)) for D1 than for D2 using dithiothreitol (DTT) as cofactor, D1 expressed in intact cells produces T(3) at free T(...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-0980
更新日期:2010-02-01 00:00:00
abstract::The expression of genes encoding key hepatic gluconeogenic enzymes, including phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), is regulated at the transcriptional level by a network of transcription factors and cofactors, including cAMP response element-binding protein (CREB). It has been ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-0641
更新日期:2010-02-01 00:00:00
abstract::Invasion of human trophoblasts is promoted through activation of wingless (Wnt) signaling, suggesting a role of the pathway in placental development and morphogenesis. However, details on the process such as involvement of canonical and/or noncanonical Wnt signaling cascades as well as their target genes are largely u...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-0557
更新日期:2010-01-01 00:00:00
abstract::An increased activity of the hypothalamo-pituitary-adrenal axis resulting in exaggerated glucocorticoid secretion has been repeatedly described in patients with diabetes mellitus and in animal models of this disease. However, it has been pointed out that experimental diabetes is accompanied by a decreased glucocortico...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-0592
更新日期:2010-01-01 00:00:00
abstract::The present studies aimed to identify mechanisms contributing to amylin/leptin synergy in reducing body weight and adiposity. We reasoned that if amylin/leptin harnessed complementary neuronal pathways, then in the leptin-sensitive state, amylin should augment leptin signaling/binding and that in the absence of endoge...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-0546
更新日期:2010-01-01 00:00:00
abstract::Recent work in sheep has identified a neuronal subpopulation in the arcuate nucleus that coexpresses kisspeptin, neurokinin B, and dynorphin (referred to here as KNDy cells) and that mediate the negative feedback influence of progesterone on GnRH secretion. We hypothesized that sex differences in progesterone negative...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-0541
更新日期:2010-01-01 00:00:00
abstract::Kisspeptin is the product of the Kiss1 gene that regulates GnRH secretion. In sheep, Kiss1 mRNA-expressing cells are found in the preoptic area (POA) and arcuate nucleus (ARC), and expression is up-regulated in the caudal ARC during the periovulatory period. We hypothesized that kisspeptin neurons in the ARC are activ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-0712
更新日期:2009-12-01 00:00:00
abstract::Estradiol (E(2)) rapidly and strongly induces vascular endothelial growth factor (VEGF) transcription in uterine endometrial epithelial cells in vivo. We have shown that this is mediated by both the estrogen receptor-alpha and hypoxia-inducible factor (HIF)-1alpha. By contrast, E(2) induces little or no VEGF expressio...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-0884
更新日期:2009-12-01 00:00:00
abstract::The GnRH decapeptide controls reproductive function through its release from neuroendocrine terminals in the median eminence, a site where there is a convergence of numerous nerve terminals and glial cells. Previous work showed dynamic changes in the GnRH-glial-capillary network in the median eminence under different ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-0679
更新日期:2009-12-01 00:00:00